[February 21] Study Looks at Nasal Spray as a Prevention of COVID-19 Transmission
The authors of a recently published report designed lipopeptide fusion inhibitors that aim to block the first critical step of infection of SARS-CoV-2‒membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. According to the study, they selected a dimeric form for evaluation in ferrets and found that "daily intranasal administration to the ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour co-housing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2." This study was published in Science on February 17. Read the published paper.
Infectious Diseases Society of America (IDSA) Guidelines on the Diagnosis of COVID-19
Access the full guidelines HERE. Content specific to testing from IDSA can be found in the following locations of the guidelines:
- The Executive Summary includes an algorithm based on 15 recommendations for SARS-CoV-2 nucleic acid testing based on systematic reviews of the diagnostic literature. (Figure 1).
- Recommendation 15: The IDSA panel suggests SARS-CoV-2 RNA testing in asymptomatic individuals without a known exposure to COVID-19 who are undergoing a time-sensitive aerosol generating procedure (e.g., bronchoscopy) when PPE is limited, and testing is available (conditional recommendation, very low certainty of evidence).
[July 28] Research: Can COVID-19 Cause Hearing Problems?
A number of journal articles have been published looking at the effects of COVID-19 on a person's hearing. The Science Times reported on this topic by highlighting the findings, which include case study reviews of COVID-19 patients experiencing hearing loss and ringing in the ears, exploring the link between viral infection and hearing problems, and addressing the concern of ototoxicity from the medication used to treat COVID-19. The Science Times provides direct links to each manuscript and notes, “More studies are needed to prove these claims. Preferably done in a larger sample and tested before and after getting the infection.” Read More.
- [Research Letter from JAMA] Correlation Between N95 Extended Use and Reuse and Fit Failure in an Emergency Department Access the Article Here. Authors: Nida F. Degesys, MD; Ralph C. Wang, MD, MAS; Elizabeth Kwan, MD; Jahan Fahimi, MD, MPH; Jeanne A. Noble, MD, MA; Maria C. Raven, MD, MPHJAMA. 2020;324(1):94-96. doi:10.1001/jama.2020.9843.
- [Research] What Impact Has COVID-19 Had on Outpatient Visits? [April 23]
- [Research] Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic Givi B, Schiff BA, Chinn SB, et al. Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic. JAMA Otolaryngol Head Neck Surg. Published online March 31, 2020. doi:10.1001/jamaoto.2020.0780.
- [Research] Surgical Considerations for Tracheostomy During the COVID-19 Pandemic Tay JK, Khoo ML, Loh WS. Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak. JAMA Otolaryngol Head Neck Surg. Published online March 31, 2020. doi:10.1001/jamaoto.2020.0764
- [Research]Olfactory and Gustatory Dysfunctions as a Clinical Presentation of Mild to Moderate forms of the Coronavirus Disease (COVID-19): A Multicenter European Study, accepted for publication in Eur Arch Otorhinolaryngol
- [Research] Anosmia outbreak in Iran: Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak, preprint shared by author Seyed Hamidreza Bagheri, MD.
- [Resource] Handbook of COVID-19 Prevention and Treatment, The First Affiliated Hospital, Zhejiang University School of Medicine, Compiled According to Clinical Experience, Editor Prof. Tingbo LIANG
- [Research] PRECAUTIONS FOR ENDOSCOPIC TRANSNASAL SKULL BASE SURGERY DURING THE COVID-19 PANDEMIC
- [Commentary] COVID-19 and Ear Surgery, (RK Jackler, Stanford)
- [Video] Stanford Medicine OHNS ENT Town Hall Regarding COVID-19 The AAO-HNS would like to thank Robert K. Jackler, MD and the Stanford Department of Otolaryngology-Head and Neck Surgery for the incredible effort required to produce the following Town Hall meeting on COVID-19 and for their willingness to share their information with all otolaryngologists.
- [Research] Content Related to Coronavirus in Annals of Internal Medicine
- [Research] Safe tracheostomy for patients with severe acute respiratory syndrome. Wei WI et al. Laryngoscope. (2003)