Cochlear Implantation in Very Young Children With Single-Sided Deafness
Abstract Objective Cochlear implants (CIs) for single-sided deafness (SSD) have only been approved for patients 5 years and older despite data supporting that younger children can also benefit from implantation. This study describes our institution's experience with CI for SSD in children 5…
Cochlear Implantation in US Military Veterans: A Single Institution Study
Volume7, Issue2Abstract Objective Military veterans have high rates of noise-induced hearing loss (NIHL) which is associated with more significant spiral ganglion neuronal loss. This study explores the relationship between NIHL and cochlear implant (CI) outcomes in veterans. Study Design Retrospective case series of veterans who…
Azithromycin Mechanisms of Action in CRS Include Epithelial Barrier Restoration and Type 1 Inflammation Reduction
Abstract Objective Previous in vitro transcriptomic profiling suggests azithromycin exerts its effects in patients with chronic rhinosinusitis (CRS) via modulation of type 1 inflammation and restoration of epithelial barrier function. We wished to verify these postulated effects using in vitro models of epithelial repair and…
Genetic Underpinnings and Audiological Characteristics in Children With Unilateral Sensorineural Hearing Loss
Abstract Objective Unilateral sensorineural hearing loss (USNHL) is a condition commonly encountered in otolaryngology clinics. However, its molecular pathogenesis remains unclear. This study aimed to investigate the genetic underpinnings of childhood USNHL and analyze the associated audiological features. Study Design Retrospective analysis of a prospectively…
Utility of Intraoperative Radiographs in Pediatric Cochlear Implant Surgery
Abstract Objective To evaluate the role of intraoperative radiographs to confirm electrode position following pediatric cochlear implantation (CI). Study Design Retrospective chart review. Setting Single tertiary care pediatric center. Methods A retrospective chart review was conducted, including all pediatric patients undergoing CI at UPMC Children…
Bilateral Congenital Ossicular Anomalies: Are the Anomalies Symmetric for Both Ears?
Abstract Objective To evaluate whether bilateral congenital ossicular anomalies (COAs) differ regarding ossicular anomalies and hearing loss severities between the ears of the individual. Study Design Retrospective case review. Setting Tertiary referral academic center. Methods Between March 2012 and December 2022, 7 consecutive patients (14…
Otorhinologic Disorders in 22q11.2 Deletion Syndrome
Abstract Objective Investigate incidence and natural history of otologic and sinonasal disease associated with 22q11.2 deletion syndrome. Study Design Case series. Setting Tertiary care children's hospital. Methods Charts from consecutive children born 2000 to 2018 with a diagnosis of 22q11.2 deletion, DiGeorge…
Health-Related Quality of Life in Children With Unilateral Sensorineural Hearing Loss Following Cochlear Implantation
Volume168, Issue6Abstract Objective Evaluate health-related quality of life (HR-QOL) benefits with cochlear implantation (CI) in children with unilateral sensorineural hearing loss (USNHL) versus bilateral sensorineural hearing loss (BSNHL). Study Design A cross-sectional survey of parents of children who underwent CI for USNHL and…
Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank
Abstract Objective To explore the association between body composition and sensorineural hearing loss (SNHL). Study Design Cross-sectional study, prospective study and Mendelian randomization (MR) analyses. Setting UK Biobank. Methods This cross-sectional study included 147,296 adult participants with complete data on body composition…
Understanding Barriers to Timely Diagnosis and Intervention Among Immigrant Children With Hearing Loss
Abstract Objective Identify the age at diagnosis and intervention of immigrant and/or non-English-speaking children with hearing loss (HL) and risk factors associated with delays. Identify barriers for non-English-speaking caregivers of deaf/hard-of-hearing children. Study Design Sequential mixed methods…
Audiometric and Patient-Reported Outcomes in Single-Sided Deafness Cochlear Implant Recipients Using the CIQOL-35
Volume168, Issue5Abstract Objective Describe the effect that cochlear implantation (CI) has on audiometric outcomes and quality of life (QOL) in patients with single-sided deafness (SSD). Study Design Retrospective case review. Setting Tertiary university hospital system. Methods Preoperative and postoperative AzBio performance and Cochlear Implant Quality…
Esophageal Schwannoma Presenting as Neck Mass and Misdiagnosed as Thyroid Nodule: A Case Report
Volume7, Issue1Benign esophageal tumors are rare, occurring at an incidence of <5%.1 Most are asymptomatic and incidentally found by imaging or endoscopy performed for other indications. Because esophageal carcinoma is approximately 50 times more common, the definitive diagnosis of a benign tumor is confirmed by…
Systematic Review and Meta-analysis of the Influence of Genetic Variation on Ototoxicity in Platinum-Based Chemotherapy
Volume168, Issue6Abstract Objective The objective of this meta-analysis is to evaluate the impact of genetic polymorphisms on platinum-based chemotherapy (PBC)-induced ototoxicity. Data Sources Systematic searches of PubMed, Embase, Cochrane, and Web of Science were conducted from the inception of the databases to May…
Olfaction and Gustation in Children With Primary Ciliary Dyskinesia
Volume7, Issue1Abstract Objective Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder whereby abnormal cilia cause a wide array of respiratory tract manifestations including chronic rhinosinusitis. The purpose of this study was to determine whether olfaction and gustation are impaired in children with PCD. Study…
Vertebral Anomalies in Microtia Patients at a Tertiary Pediatric Care Center
Abstract Objective Microtia is a congenital condition known to be associated with vertebral anomalies and congenital syndromes, most prominently hemifacial microsomia. There is controversy, however, on whether to screen with spinal imaging. Additionally, microtia ear reconstruction utilizes rib harvesting that could potentially worsen pre-existing…
Prognostic Significance of a Model Based on Acetaldehyde Dehydrogenase 2 Genetic Polymorphisms in Laryngeal Carcinoma
Abstract Objective Because of the high costs associated with early-stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers. Study…
Reduced Risk of Corporal Tumors in Patients With Head and Neck Paragangliomas With p.Pro81Leu Mutations
Abstract Objective Patients with head and neck paragangliomas who are positive for the SDHD p.Pro81Leu (P81L) mutation are thought to have a distinct phenotype from other SDHx mutations, but few studies have focused on this mutation. The objective of this study was to determine…
